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Selective estrogen receptor modulator with estrogen-agonistic effects on bone and lipid metabolism.

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Raloxifene should not be used for the primary or secondary prevention of cardiovascular disease.

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Tony Buffington, professor of veterinary clinical services at Ohio State University Veterinary Hospital, Columbus.

Health Initiative Study of Cognitive Aging (WHISCA).

When a bone-sparing dose (0.

The selective estrogen receptor modulator, raloxifene: reproductive assessments following premating exposure in female rats.

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Solid State Interaction of Raloxifene HCl with Different Hydrophilic Carriers During Co-grinding and its Effect on Dissolution Rate.

It decreases bone resorption ()() and serum LDL-cholesterol ()()(), but it does not stimulate breast () or endometrium () at the recommended dosage of 60 mg daily.

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Raloxifene is a less potent antiresorptive agent than bisphosphonates.

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Over time, this led scientists to believe that embryonic stem cells could be used as a sort of vaccine against tumors.

Risk of uterine cancer goes back to normal within a few years of stopping the drug.

Seventy-five moderately oligospermic patients showed significant improvement in the sperm density, total sperm count and motility following mesterolone therapy whereas only 12% showed improvement in the severe oligospermic group.

Lamuela-Raventos RM, Romero-Perez AI, Waterhouse AL, de la Torre-Boronat MC; Romero-Perez; Waterhouse; de la Torre-Boronat (1995).

Estrogenic properties of raloxifene, but not tamoxifen, on D2 and D3 dopamine receptors in the rat forebrain.

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Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO).

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Denosumab (Prolia) is a new type of antiresorptive medication that works differently than bisphosphonates.

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At LEAST TWO WEEKS of SERM treatment should have passed before a therapeutic failure is declared and the dose adjusted accordingly.

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The effect of raloxifene hydrochloride on the incidence of invasive breast cancer was evaluated for 4 additional years in a follow-up study conducted in a subset of postmenopausal women originally enrolled in the MORE osteoporosis treatment trial.

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Differential impact of conventional oral or transdermal hormone replacement therapy or tibolone on body composition in postmenopausal women.

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Raloxifene patients also had a significant reduction in PANSS general symptom scores compared with those receiving placebo (difference -3.

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Khodaie-Ardakani MR, Mirshafiee O, Farokhnia M, Tajdini M, Hosseini SM, Modabbernia A, Rezaei F, Salehi B, Yekehtaz H, Ashrafi M, Tabrizi M, Akhondzadeh S: Minocycline add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: Randomized double-blind placebo-controlled study.

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